Symptomatic
lymphoid interstitial pneumonitis |
Definitive diagnosis: Chest.X-ray:
bilateral reticulonodular interstitial pulmonary infiltrates present
for more than two months with no response to antibiotic treatment
and no other pathogen found. Oxygen saturation persistently <90%.
Cor pulmonale and increased exercise-induced fatigue. Characteristic
histology. |
Case 1 a 2-year-old child |
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A chest radiograph of a 2-year-old child
shows interstitial infiltrates and reticulonodular patterns. |
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She had generalized lymphadenopathy |
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She had hyperemia of the distal part of the fingers
(early clubbing of the digits). |
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Case 2 a 3-year-old child |
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A chest radiograph of a 3-year-old child shows interstitial
infiltrates and reticulonodular patterns. |
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Note:
She also had parotitis and generalized lymphadenopathy. |
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Case 3 a 4-year-old child |
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A chest radiograph of a 4-year-old child shows interstitial
infiltrates and reticulonodular patterns. |
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She had clubbing of the digits. |
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Computed tomography of the chest |
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Hematoxylin-eosin staining of a lung biopsy specimen
demonstrating lymphoid interstitial pneumonitis. Diffuse
infiltration of interstitial and alveolar space by lymphocytes
and plasma cells.
The infiltrated lymphocytes are both B cells and T cells
with
predominance of T-suppressor cells
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