A 4-year-old child with fungal nail infection. Fungal nail infections are more likely to appear in people with HIV infection.

The most common clinical pattern is a distal subungual type in which the infection is found underneath the nail towards the tip or end of the nail. The infection is recognized by the separation of the nail plate from the nail bed with yellowish thickening of the nail plate. Topical therapy in usually not effective. Treatment with oral antifungal drugs is effective, but hepatotoxicity, drug interactions and cardiotoxicity should be monitored.