Unexplained persistent parotid enlargement
Asymptomatic bilateral swelling that may spontaneously resolve and recur, in absence of other known cause; usually painless.

Nonspecific bilateral painless enlargement of the parotid glands are seen in this 3-year-old HIV-infected girl. It is commonly found in HIV-infected children.

It may spontaneously resolve and recur. The most common histologic finding is benign lymphoepithelial lesions (BLL). BLL are intraparotid pathologic changes consisting of marked lymphoid hyperplasia accompanied by squamous-lined cysts or mixed masses with solid components.

3-year-old girl with parotitis and lymphoid interstitial pneumonitis (Figure A, B and C)

A) The parotitis was the presenting symptoms in this 3-year-old HIV-infected child.

B) They were painless.
C) She also had interstitial infiltrations in her lungs.
D) She had hyperemia of the distal part of the fingers. This demonstrated "early clubbing of the fingers", which was the result of chronic hypoxia.
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