Non-NIH, Project.

Determinants of resilience in youth with HIV infection and youth affected by HIV

HIVNAT 217:

Study title

Determinants of resilience in youth with HIV infection and youth affected by HIV

Study Code

HIVNAT 217

Network

HIVNAT

Study PI

Wasana Prasitsuebsai, MD

Study Co PI

Linda Aurpibul, M.D.

Study sites

Thailand

  1. Faculty of Medicine, Chulalongkorn University and the HIV Netherlands Australia Thailand Research Collaboration (HIV-NAT), the Thai Red Cross AIDS Research Centre, Bangkok, Thailand
  2. Bamrasnaradura Infectious Diseases Institute, Nonthaburi, Thailand
  3. Srinagarind Hospital, Khon Kean University, Khon Kean, Thailand
  4. Queen Savang Vadhana Memorial Hospital, Chonburi, Thailand
  5. Nakornping Hospital, Chiang Mai, Thailand
  6. Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand
  7. Prapokklao Hospital, Chantaburi, Thailand
  8. Research Institute for Health Science and Faculty of Medicine Chiang Mai University

Cambodia

  1. National Pediatric Hospital, Phnom Penh, Cambodia
  2. Social Health Clinic, Phnom Penh, Cambodia

Funding agency

National Institute of Mental Health, National Institutes of Health, USA

Study design

prospective observational cohort study

Study objective

Objective 1: To identify the determinants of resilience in paHIV+ and HEU adolescents

Objective 2: To determine the neuroanatomical correlates for resilience

Objective 3: To examine determinants of resilience across culturally different settings, critical to assessment and treatment across contexts

Number of enrolled participants (overall/at RIHES)

Youth aged >10 years old will be included. They will be from the following groups

280 HIV-infected youth from the PREDICT cohort (140 immediate ART and 140 deferred ART)

150 perinatally HIV-exposed/HIV-negative youth

150 HIV-unexposed/HIV-negative youth

For Faculty of Medicine and Research Institutes for Health Sciences (RIHES), Chiang Mai University will enroll approximately 80 participants to the study.

 
Year: started

October 2014

Year: expected to finish

October 2018

Significance

The evaluation of resilience in adolescents as a sub study of PREDICT is relevant for the following reasons:

There are limited data about resilience determinants in HIV infected youth who have initiated ARVs at different CD4 percentages, do not have AIDS defining illnesses (CDC C), have not been exposed to substance use while in utero and are from resource-limited setting. This study will complement the main PREDICT study as well as other substudies, especially the neurodevelopment substudy, in obtaining knowledge to design appropriate and effective preventive interventions that will help promote health among paHIV+ and HEU youth worldwide to successfully transition into adulthood and the workforce.

There is limited information on the development of the prefrontal cortex in paHIV+ youth and its links to resilience.

No one has assessed the cognitive, neuroimaging, behavioral and mental health outcomes among adolescents with paHIV+ and HEU across different cultures.

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